As If Biomarker Discovery Isn't Hard Enough: The Consequences of Poorly Characterized Reagents
نویسندگان
چکیده
منابع مشابه
As if biomarker discovery isn't hard enough: the consequences of poorly characterized reagents.
The advent of high-throughput “-omic” technologies over the past 2 decades has driven a vast expansion in the search for clinical biomarkers, as manifested by the plethora of publications on biomarker discovery (over 8600) listed on PubMed since 2000. Unfortunately, the same time period has seen a relative dearth of clinically validated biomarkers that have received Food and Drug Administration...
متن کاملImproving the quality of biomarker discovery research: the right samples and enough of them.
BACKGROUND Biomarker discovery research has yielded few biomarkers that validate for clinical use. A contributing factor may be poor study designs. METHODS The goal in discovery research is to identify a subset of potentially useful markers from a large set of candidates assayed on case and control samples. We recommend the PRoBE design for selecting samples. We propose sample size calculatio...
متن کاملCaenorhabditis evolution: if they all look alike, you aren't looking hard enough.
Caenorhabditis elegans is widely known as a model organism for cell, molecular, developmental and neural biology, but it is also being used for evolutionary studies. A recent meeting of researchers in Portugal covered topics as diverse as phylogenetics, genetic mapping of quantitative and qualitative intraspecific variation, evolutionary developmental biology and population genetics. Here, we s...
متن کاملProteomics as a Tool for Biomarker Discovery
Novel technologies are now being advanced for the purpose of identification and validation of new disease biomarkers. A reliable and useful clinical biomarker must a) come from a readily attainable source, such as blood or urine, b) have sufficient sensitivity to correctly identify affected individuals, c) have sufficient specificity to avoid incorrect labeling of unaffected persons, and d) res...
متن کاملIf it was good enough for Aristotle......
‘If you want to understand today you have to search yesterday ’ wrote the American novelist Pearl Buck, and such is the challenge facing those who hope to disentangle the pathogenesis of idiopathic pulmonary fibrosis (IPF). The disease is characterised by the insidious but progressive development of fibrosis that culminates in respiratory failure and death, usually within 5 years of diagnosis. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2014
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2013.216382